| Title | [Anti-inflammatory effects of pentoxifylline : Importance in cardiac surgery.] | | Author(s) | Groesdonk HV, Heringlake M, Heinze H | | Institution | Klinik für Thorax- und Herz-Gefässchirurgie, Universitätskliniken des Saarlandes, Kirrbergerstr., 66421, Homburg/Saar, Deutschland, medicine@groesdonk.net. | | Source | Anaesthesist 2009 Nov 6. | | Abstract | Initially introduced as a rheologic agent for use in intermittent claudication due to peripheral artery disease and in ischemic cerebrovascular disease, the methylxanthine derivative pentoxifylline (PTX) has been shown to possess several anti-inflammatory properties which make this drug an interesting immunomodulating adjunct for the management of patients undergoing cardiac surgery. As an unspecific phosphodiesterase inhibitor PTX ameliorates the inflammatory response following a septic stimulus and blunts organ dysfunction after ischemia-reperfusion injury. Apart from this several small clinical studies have shown that the use of PTX may blunt the inflammatory response induced by cardiac surgery using a cardiopulmonary bypass. Additionally it has been shown that the perioperative application of this drug may improve postoperative function of organs at risk, such as the kidneys and liver. | | Language | GER | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19890615 |
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